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The clinical manifestations of AAD can vary from mild diarrhea to fulminant colitis. The seriousness of C. difficile colitis seems to become affected by an array of factors, including age, comorbidity, host's immune response, and using antiperistaltic agents. Oddly enough, microbial genotype and contaminant production seem to play minimal roles. The cardinal characteristic of the condition is diarrhea, which generally evolves throughout treatment but may seem as late as 8 days after discontinuation of anti-biotics. Generally of AAD, patients present with loose stools, minimal signs and symptoms of colitis, with no constitutional signs and symptoms. The diarrhea quickly responds to encouraging measures and withdrawal from the antimicrobial agent.

In comparison, typical cases of C. difficile infection manifest having a profuse, mucous, foul-smelling diarrhea connected with cramps and tenesmus. Frank bleeding is rare, although fecal occult bloodstream and leukocytes are often detected. The abdomen is usually soft, with elevated bowel sounds and mild tenderness within the left lower quadrant. Constitutional signs and symptoms are typical, and can include nausea, vomiting, lack of fluids, and low-grade fever. Mild leukocytosis is often present and could occur even even without the diarrhea. An periodic leukemoid reaction continues to be reported. For colitis limited right colon, prominent findings of localized abdominal discomfort, leukocytosis, and fever are available in the existence of minimal diarrhea.